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Peptide record

TPDB24073

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB24073
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, AFP-GFuse, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NEPTHLLKAFSKAGFQ
Physicochemical Analysis
C82H126N22O23
RDCIMWYV
ALKF
1788.04
9.88
3
1
6
+1
2.97
-0.512
61.25
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
1
Q
1
G
1
H
0
I
2
L
2
K
0
M
2
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 0 L: 2 K: 2 M: 0 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C82H126N22O23
1788.04
9.88
+1
2.97
-0.512
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100-200 µM

Target

S.agalactiae ATCC12386

Source & Reference

NA

Other

alis IOC 4560, C. neoformans H99, A. niger A296 (all MIC 50-100 uM), P.farinosus IBC 251, S.agalactiae ATCC12386 (MIC 100-200 uM), bacteria M. luteus A270, S. aureus ATCC 29213 (MIC 25-50 uM), inactive: C.glabrata IOC 4
Evidence 2 Activity

Activity

MIC
Antibacterial
25-50 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

), P.farinosus IBC 251, S.agalactiae ATCC12386 (MIC 100-200 uM), bacteria M. luteus A270, S. aureus ATCC 29213 (MIC 25-50 uM), inactive: C.glabrata IOC 4565, C.krusei IOC 4559, A.fumigatus (bread isolated), B.bassia
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

us (bread isolated), B.bassiana (mummified spider isolated), P.expansum (bread isolated), P. aeruginosa ATCC 27853 (MIC 12.5-25 uM), P.aeruginosa PA14, E.coli D31 or DH5-alpha.
Evidence 4 Activity

Activity

MIC
Antifungal
100-200 µM

Target

S.agalactiae ATCC12386

Source & Reference

NA

Other

alis IOC 4560, C. neoformans H99, A. niger A296 (all MIC 50-100 uM), P.farinosus IBC 251, S.agalactiae ATCC12386 (MIC 100-200 uM), bacteria M. luteus A270, S. aureus ATCC 29213 (MIC 25-50 uM), inactive: C.glabrata IOC 4
Evidence 5 Activity

Activity

MIC
Antifungal
25-50 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

), P.farinosus IBC 251, S.agalactiae ATCC12386 (MIC 100-200 uM), bacteria M. luteus A270, S. aureus ATCC 29213 (MIC 25-50 uM), inactive: C.glabrata IOC 4565, C.krusei IOC 4559, A.fumigatus (bread isolated), B.bassia
Evidence 6 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

us (bread isolated), B.bassiana (mummified spider isolated), P.expansum (bread isolated), P. aeruginosa ATCC 27853 (MIC 12.5-25 uM), P.aeruginosa PA14, E.coli D31 or DH5-alpha.
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
0% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus | bioRxiv | 2022