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Peptide record

TPDB23972

Antibacterial Antifungal standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB23972
Antibacterial Antifungal
Anti-infective peptides
Peptipedia CAFPdb
standard
No
A 31-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
MTKKQKRKKGIKTKSAGRFGARYGRRIRKAI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C158H284N58O37S1
NDCEHLPWV
K
3620.42
12.72
14
0
9
+14
3.83
-1.394
47.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
0.41
5
Residue Composition
number
3
A
6
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
3
I
0
L
8
K
1
M
1
F
0
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 3 L: 0 K: 8 M: 1 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
31 reviewed residue count
C158H284N58O37S1 sequence-only estimate (linear, free termini)
3620.42 sequence-only estimate (linear, free termini)
12.72 sequence-only estimate (linear, free termini)
+14 sequence-only estimate (linear, free termini)
3.83 sequence-only estimate (linear, free termini)
-1.394 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8.84 µM

Target

C. neoformans H99

Source & Reference

NA

Other

C-albicans SC5314 (MIC >71.71 uM), C-krusei IFM56881(MIC >70.71 uM), C. neoformans H99 (MIC 8.84 uM), C. parapsilosis ATCC22019 (MIC 4.42 uM) ( Zhang et al., 2022 ).
Evidence 2 Activity

Activity

MIC
Antibacterial
4.42 µM

Target

C. parapsilosis ATCC22019

Source & Reference

NA

Other

C5314 (MIC >71.71 uM), C-krusei IFM56881(MIC >70.71 uM), C. neoformans H99 (MIC 8.84 uM), C. parapsilosis ATCC22019 (MIC 4.42 uM) ( Zhang et al., 2022 ).
Evidence 3 Activity

Activity

MIC
Antifungal
8.84 µM

Target

C. neoformans H99

Source & Reference

CAFPdb

Other

C-albicans SC5314 (MIC >71.71 uM), C-krusei IFM56881(MIC >70.71 uM), C. neoformans H99 (MIC 8.84 uM), C. parapsilosis ATCC22019 (MIC 4.42 uM) ( Zhang et al., 2022 ).
Evidence 4 Activity

Activity

MIC
Antifungal
4.42 µM

Target

C. parapsilosis ATCC22019

Source & Reference

CAFPdb

Other

C5314 (MIC >71.71 uM), C-krusei IFM56881(MIC >70.71 uM), C. neoformans H99 (MIC 8.84 uM), C. parapsilosis ATCC22019 (MIC 4.42 uM) ( Zhang et al., 2022 ).