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Peptide record

TPDB23770

Antibacterial Antifungal standard
126 amino acids
Basic Information
3D PDB MODEL
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TPDB23770
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 126-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C612H1022N182O180S3
CW
K
13906.14
10.75
31
10
44
+18
2.26
-0.738
68.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7450
0.54
33
Residue Composition
number
13
A
8
R
3
N
3
D
0
C
7
E
3
Q
7
G
3
H
6
I
6
L
20
K
3
M
2
F
6
P
14
S
8
T
0
W
5
Y
9
V
Amino Acid Distribution
A: 13 R: 8 N: 3 D: 3 C: 0 E: 7 Q: 3 G: 7 H: 3 I: 6 L: 6 K: 20 M: 3 F: 2 P: 6 S: 14 T: 8 W: 0 Y: 5 V: 9
Chemical Descriptors
126 reviewed residue count
C612H1022N182O180S3 sequence-only estimate (linear, free termini)
13906.14 sequence-only estimate (linear, free termini)
10.75 sequence-only estimate (linear, free termini)
+18 sequence-only estimate (linear, free termini)
2.26 sequence-only estimate (linear, free termini)
-0.738 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

Escherichia coli JCM5419

Source & Reference

NA

Other

Active against E. coli JCM5419 (MIC 7.5 ug/ml) and E. coli BL21(DE3) (MIC 60 ug/ml).
Evidence 2 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

Escherichia coli JCM5419

Source & Reference

Antifungipept

Other

Active against E. coli JCM5419 (MIC 7.5 ug/ml) and E. coli BL21(DE3) (MIC 60 ug/ml).