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Peptide record

TPDB23550

Anti-inflammatory Antibacterial Anticancer Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB23550
Anti-inflammatory Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia
standard
No
A 22-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKKLLLILFCLALALAGCKKAP
Physicochemical Analysis
C111H196N26O23S3
RNDEQHSTWYV
L
2359.12
10.17
4
0
14
+4
-2.33
1.382
160.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
5.30
2
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
7
L
4
K
1
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 7 K: 4 M: 1 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C111H196N26O23S3
2359.12
10.17
+4
-2.33
1.382
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

Enterococcus faecalis JH2-2

Source & Reference

NA

Other

Active against S. aureus ATCC 33591 or USA300 (MRSA, MIC 16-64 ug/ml), E.faecalis JH2-2 (MIC 256 ug/ml), L. monocytogenes (), K.pneumoniae (MIC 512 ug/ml or higher), A. baumannii sensitive (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
16-32 µg/mL

Target

A. baumannii sensitive

Source & Reference

NA

Other

calis JH2-2 (MIC 256 ug/ml), L. monocytogenes (), K.pneumoniae (MIC 512 ug/ml or higher), A. baumannii sensitive (MIC 16-32 ug/ml), A.baumannii IMI, MER, OXA-23, OXA-50 (MIC 128-256 ug/ml), E.coli, S.typhimurium, B.cereu
Evidence 3 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

B.cereus

Source & Reference

NA

Other

ug/ml), A.baumannii IMI, MER, OXA-23, OXA-50 (MIC 128-256 ug/ml), E.coli, S.typhimurium, B.cereus (MIC 256 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aerugi
Evidence 4 Activity

Activity

MIC
Antibacterial
>512 µg/mL

Target

P.aeruginosa PAO1

Source & Reference

NA

Other

MER, OXA-23, OXA-50 (MIC 128-256 ug/ml), E.coli, S.typhimurium, B.cereus (MIC 256 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aeruginosa C3719 or LES400 (MIC 64 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Pseudomonas aeruginosa C3719 or LES400

Source & Reference

NA

Other

56 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aeruginosa C3719 or LES400 (MIC 64 ug/ml).
Evidence 6 Activity

Activity

IC50
Toxicity
96±21 µg/mL
Cytotoxic
IC50 | 96±21 | µg/mL | target cell: Human Lung Fibroblasts IMR-90

Target

Human Lung Fibroblasts IMR-90

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 7 Activity

Activity

IC50
Toxicity
120±25 µg/mL
Cytotoxic
IC50 | 120±25 | µg/mL | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
409±67 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 409±67 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
NPJ Biofilms Microbiomes. 2022 Jul 14 8(1):58.