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Peptide record

TPDB23402

Antibacterial Antifungal standard

60 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB23402

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 60-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK

FASTA

>TPDB23402|Antibacterial;Antifungal|length=60
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK

Formula C270H458N74O84S2

Absent Amino Acids RNCIPW

Common Amino Acids K

Mass 6149.17

PI 10.04

Basic Residues 12

Acidic Residues 7

Hydrophobic Residues 25

Net Charge +4

Boman Index 22.34

Hydrophobicity -0.188

Aliphatic Index 76.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 24.23

Polar Residues 9

number

Amino Acid Distribution

A: 9 R: 0 N: 0 D: 1 C: 0 E: 6 Q: 1 G: 8 H: 1 I: 0 L: 2 K: 11 M: 2 F: 1 P: 0 S: 2 T: 5 W: 0 Y: 1 V: 10

Length

Formula

C270H458N74O84S2

Mass

6149.17

10.04

Net Charge

Boman Index

22.34

Hydrophobicity

-0.188

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epide

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 15692

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.3 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Evidence Text

m- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (M

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP

Other

Evidence Text

1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM),

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.4 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.4 µM

Target

Target Organism F. neoformans

Source & Reference

Database Source dbAMP

Other

Evidence Text

923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.4 µM

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP

Other

Evidence Text

ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.8 µM

Target

Target Organism R. solani

Source & Reference

Database Source dbAMP

Other

Evidence Text

yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epide

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 15692

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.3 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.4 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.4 µM

Target

Target Organism F. neoformans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.4 µM

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.8 µM

Target

Target Organism R. solani

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).