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Peptide record

TPDB23402

Antibacterial Antifungal standard
60 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB23402
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 60-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C270H458N74O84S2
RNCIPW
K
6149.17
10.04
12
7
25
+4
0.98
-0.188
76.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
0.24
9
Residue Composition
number
9
A
0
R
0
N
1
D
0
C
6
E
1
Q
8
G
1
H
0
I
2
L
11
K
2
M
1
F
0
P
2
S
5
T
0
W
1
Y
10
V
Amino Acid Distribution
A: 9 R: 0 N: 0 D: 1 C: 0 E: 6 Q: 1 G: 8 H: 1 I: 0 L: 2 K: 11 M: 2 F: 1 P: 0 S: 2 T: 5 W: 0 Y: 1 V: 10
Chemical Descriptors
60 reviewed residue count
C270H458N74O84S2 sequence-only estimate (linear, free termini)
6149.17 sequence-only estimate (linear, free termini)
10.04 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.98 sequence-only estimate (linear, free termini)
-0.188 sequence-only estimate (linear, free termini)
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epide
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Pseudomonas aeruginosa ATCC 15692

Source & Reference

dbAMP

Other

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C
Evidence 3 Activity

Activity

MIC
Antibacterial
3.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

m- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (M
Evidence 4 Activity

Activity

MIC
Antibacterial
3.2 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
6.4 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
6.4 µM

Target

F. neoformans

Source & Reference

dbAMP

Other

923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
6.4 µM

Target

A. flavus

Source & Reference

dbAMP

Other

ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
12.8 µM

Target

R. solani

Source & Reference

dbAMP

Other

yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epide
Evidence 10 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Pseudomonas aeruginosa ATCC 15692

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C
Evidence 11 Activity

Activity

MIC
Antifungal
3.3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

m- bacteria E. coli ATCC 25922 (MIC 1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (M
Evidence 12 Activity

Activity

MIC
Antifungal
3.2 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.6 uM), P. aeruginosa ATCC 15692 (MIC 1.6 uM), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
6.4 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

), Gram+ S. aureus ATCC 25923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
6.4 µM

Target

F. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

923 (MIC 3.3 uM), S. epidermidis ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 15 Activity

Activity

MIC
Antifungal
6.4 µM

Target

A. flavus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC 12228 (MIC 3.2 uM), yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
12.8 µM

Target

R. solani

Source & Reference

dbAMP CAFPdb Antifungipept

Other

yeast C. albicans (MIC 6.4 uM), F. neoformans (MIC 6.4 uM), mold A. flavus (MIC 6.4 uM), R. solani (MIC 12.8 uM).