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Peptide record

TPDB23273

Antibacterial Antifungal standard
53 amino acids
Basic Information
3D PDB MODEL
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TPDB23273
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifp Antifungipept
standard
No
A 53-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, Antifp, and Antifungipept, with an available 3D structural model.
Sequence
MAGFLKVVQLLAKYGSKAVQWAWANKGKILDWLNAGQAIDWVVSKIKQILGIK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C279H445N71O67S1
RCEHPT
K
5898.10
10.58
8
2
30
+6
-0.04
0.300
121.51
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
23490
3.98
9
Residue Composition
number
7
A
0
R
2
N
2
D
0
C
0
E
4
Q
5
G
0
H
5
I
6
L
8
K
1
M
1
F
0
P
2
S
0
T
4
W
1
Y
5
V
Amino Acid Distribution
A: 7 R: 0 N: 2 D: 2 C: 0 E: 0 Q: 4 G: 5 H: 0 I: 5 L: 6 K: 8 M: 1 F: 1 P: 0 S: 2 T: 0 W: 4 Y: 1 V: 5
Chemical Descriptors
53 reviewed residue count
C279H445N71O67S1 sequence-only estimate (linear, free termini)
5898.10 sequence-only estimate (linear, free termini)
10.58 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
-0.04 sequence-only estimate (linear, free termini)
0.300 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.8 µM

Target

Staphylococcus aureus ATCC 12600T

Source & Reference

NA

Other

eus JCM 5885 (MIC 110-330 nM), M. luteus IFO 12708, L. casei JCM 1134T (MIC 790- 900 nM), S. aureus ATCC 12600T (MIC 1.8 uM), and S. salivarius JCM 5707T (MIC 7.2 uM). Lacticin Q showed antibacterial activity compa
Evidence 2 Activity

Activity

MIC
Antibacterial
7.2 µM

Target

S. salivarius JCM 5707T

Source & Reference

NA

Other

IFO 12708, L. casei JCM 1134T (MIC 790- 900 nM), S. aureus ATCC 12600T (MIC 1.8 uM), and S. salivarius JCM 5707T (MIC 7.2 uM). Lacticin Q showed antibacterial activity comparable to that of nisin A in terms of both
Evidence 3 Activity

Activity

MIC
Antifungal
1.8 µM

Target

Staphylococcus aureus ATCC 12600T

Source & Reference

Antifungipept

Other

eus JCM 5885 (MIC 110-330 nM), M. luteus IFO 12708, L. casei JCM 1134T (MIC 790- 900 nM), S. aureus ATCC 12600T (MIC 1.8 uM), and S. salivarius JCM 5707T (MIC 7.2 uM). Lacticin Q showed antibacterial activity compa
Evidence 4 Activity

Activity

MIC
Antifungal
7.2 µM

Target

S. salivarius JCM 5707T

Source & Reference

Antifungipept

Other

IFO 12708, L. casei JCM 1134T (MIC 790- 900 nM), S. aureus ATCC 12600T (MIC 1.8 uM), and S. salivarius JCM 5707T (MIC 7.2 uM). Lacticin Q showed antibacterial activity comparable to that of nisin A in terms of both