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Peptide record

TPDB23197

Antibacterial Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB23197
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
LWGEIWNTVKGLI
Physicochemical Analysis
C74H113N17O18
ARDCQHMFPSY
GILW
1528.81
6.94
1
1
7
-0
-1.78
0.508
142.31
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
719.51
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
2
I
2
L
1
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
13
C74H113N17O18
1528.81
6.94
-0
-1.78
0.508
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
68.50 µg/mL
Cytotoxic
50% Cytotoxicity | 68.50 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Theranostics | 2018
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29290802]the cell viability of erythrocytes was also more than 95% at concentrations of Eval418 of 10 µg/mL or less. | Cytotoxicity: [Ref.29290802]Vero cell:CC50=68.50µg/mL the cell viability of the peptide-treated Vero cells was greater than 95% after treatment with Eval418 at 10 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Theranostics. 2018 Jan 1 8(1):199-211.
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29290802]The hemolysis rate of human erythrocytes was less than 50% when the concentration of Eval418 was as high as 200 µg/mL. | Cytotoxicity: [Ref.29290802]Vero cells: CC50 = 68.50 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Theranostics. 2018 Jan 1 8(1):199-211.