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Peptide record

TPDB23167

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Anticancer Antifungal Antihypertensive Bitter Toxicity Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB23167
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Anticancer Antifungal Antihypertensive Bitter Toxicity Umami iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
LV
Physicochemical Analysis
C11H22N2O3
ARNDCEQGHIKMFPSTWY
LV
230.31
6.02
0
0
2
-0
-0.49
4.000
340.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C11H22N2O3
230.31
6.02
-0
-0.49
4.000
230.3031
230.1625
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Cyclic dipeptides from rhabditid entomopathogenic nematode-associated Bacillus cereus have antimicrobial activities. | World J Microbiol Biotechnol | 2014
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Nat Prod Res. 2020 May 34(10):1461-1464
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP database of bioactive peptides peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CC(C)C InChI=1S/C11H22N2O3/c1-6(2)5-8(12)10(14)13-9(7(3)4)11(15)16/h6-9H,5,12H2,1-4H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChIKey: MDSUKZSLOATHMH-IUCAKERBSA-N Glucose uptake stimulating peptide according to BIOPEP database of bioactive peptides (ID 8321) Inhibitor of citrulline uptake in yeasts according to ChEMBL database PubChem database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) according to AHTPDB database Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
2