TPDB

3D PDB MODEL

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TPDB ID TPDB23165

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LTVSPWYGCGQLGKKKHRRRPSKKKRHW

FASTA

>TPDB23165|Antibacterial;Anticancer;Toxicity|length=28
LTVSPWYGCGQLGKKKHRRRPSKKKRHW

Formula C154H249N53O34S1

Absent Amino Acids ANDEIMF

Common Amino Acids K

Mass 3419.07

PI 12.03

Basic Residues 12

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +10

Boman Index 7.08

Hydrophobicity -1.671

Aliphatic Index 38.21

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 12490

Absorbance 280nm 365.30

Polar Residues 6

number

0

A

4

R

0

N

0

D

1

C

0

E

1

Q

3

G

2

H

0

I

2

L

6

K

0

M

0

F

2

P

2

S

1

T

2

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 3 H: 2 I: 0 L: 2 K: 6 M: 0 F: 0 P: 2 S: 2 T: 1 W: 2 Y: 1 V: 1

Length

28

Formula

C154H249N53O34S1

Mass

3419.07

PI

12.03

Net Charge

+10

Boman Index

7.08

Hydrophobicity

-1.671

Evidence 1 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 50 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Target Cell Chinese hamster ovary cells CHO-K1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 2 Activity

Activity

Activity Endpoint 10% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

10% Killing | 50 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 3 Activity

Activity

Activity Endpoint 5% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

5% Killing | 50 | µM | target cell: Human fibroblasts WI-38

Target

Target Cell Human fibroblasts WI-38

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: CHO-K1: 0%Killing=50 µM HFF: 10%Killing=50 µM WI-38: 5%Killing=50 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Oncotarget. 2016 Feb 2 7(5):5483-94.