TPDB

3D PDB MODEL

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TPDB ID TPDB23164

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LTVSPWYGCGMPFSTGKRIMLGE

FASTA

>TPDB23164|Antibacterial;Anticancer;Toxicity|length=23
LTVSPWYGCGMPFSTGKRIMLGE

Formula C114H176N28O31S3

Absent Amino Acids ANDQH

Common Amino Acids G

Mass 2531.00

PI 8.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +1

Boman Index -0.68

Hydrophobicity 0.152

Aliphatic Index 63.48

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 276.18

Polar Residues 6

number

0

A

1

R

0

N

0

D

1

C

1

E

0

Q

4

G

0

H

1

I

2

L

1

K

2

M

1

F

2

P

2

S

2

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 2 K: 1 M: 2 F: 1 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 1

Length

23

Formula

C114H176N28O31S3

Mass

2531.00

PI

8.88

Net Charge

+1

Boman Index

-0.68

Hydrophobicity

0.152

Evidence 1 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 50 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Target Cell Chinese hamster ovary cells CHO-K1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 2 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 50 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 3 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 50 | µM | target cell: Human fibroblasts WI-38

Target

Target Cell Human fibroblasts WI-38

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: CHO-K1: 0%Killing=50 µM HFF: 0%Killing=50 µM WI-38: 0%Killing=50 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Oncotarget. 2016 Feb 2 7(5):5483-94.