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Peptide record

TPDB23163

Antibacterial Anticancer Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB23163
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LTVSPWYGCGKLAKLAKKLAKLAK
Physicochemical Analysis
C122H207N31O28S1
RNDEQHIMF
K
2588.24
10.60
6
0
12
+6
0.24
0.142
110.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
6990
270.07
4
Residue Composition
number
4
A
0
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
5
L
6
K
0
M
0
F
1
P
1
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 6 M: 0 F: 0 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
24
C122H207N31O28S1
2588.24
10.60
+6
0.24
0.142
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Killing
Toxicity
10 µM
Cytotoxic
0% Killing | 10 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 2 Activity

Activity

100% Killing
Toxicity
50 µM
Cytotoxic
100% Killing | 50 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 3 Activity

Activity

0% Killing
Toxicity
10 µM
Cytotoxic
0% Killing | 10 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 4 Activity

Activity

80% Killing
Toxicity
50 µM
Cytotoxic
80% Killing | 50 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 5 Activity

Activity

0% Killing
Toxicity
10 µM
Cytotoxic
0% Killing | 10 | µM | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 6 Activity

Activity

55% Killing
Toxicity
50 µM
Cytotoxic
55% Killing | 50 | µM | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy. | Oncotarget | 2016
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: CHO-K1: 100%Killing=50 µM HFF: 80%Killing=50 µM WI-38: 55%Killing=50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Oncotarget. 2016 Feb 2 7(5):5483-94.