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Peptide record

TPDB23129

Antibacterial Antifungal Toxicity modified_plain modified
8 amino acids
Basic Information
3D PDB MODEL
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TPDB23129
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 8-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
LRXLRXXX
Physicochemical Analysis
C24H48N10O5
ANDCEQGHIKMFPSTWYV
RL
556.71
12.40
2
0
2
+2
0.50
-0.175
97.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C24H48N10O5
556.71
12.40
+2
0.50
-0.175
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>450 µM
Hemolytic Cytotoxic
50% Hemolysis | >450 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 2 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
420 µM
Hemolytic Cytotoxic
50% Hemolysis | 420 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
255 µM
Hemolytic Cytotoxic
50% Hemolysis | 255 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 5 Activity

Activity

12% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
12% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015