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Peptide record

TPDB23128

Antibacterial Antifungal Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB23128
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
LRXLRXX
Physicochemical Analysis
C24H48N10O5
ANDCEQGHIKMFPSTWYV
RL
556.71
12.40
2
0
2
+2
0.50
-0.200
111.43
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C24H48N10O5
556.71
12.40
+2
0.50
-0.200
Evidence Records 7 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
230 µM
Hemolytic Cytotoxic
50% Hemolysis | 230 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
22% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
22 µM
Hemolytic Cytotoxic
50% Hemolysis | 22 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
100% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
50% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
265 µM
Hemolytic Cytotoxic
50% Hemolysis | 265 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 7 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015