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Peptide record

TPDB23121

Antibacterial Antifungal Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB23121
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
LRWLRWG
Physicochemical Analysis
C48H71N15O8
ANDCEQHIKMFPSTYV
RLW
986.19
12.40
2
0
4
+2
-3.19
-0.514
111.43
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
1115.41
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
7
C48H71N15O8
986.19
12.40
+2
-3.19
-0.514
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 2 Activity

Activity

<8% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
<8% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015