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Peptide record

TPDB23109

Antibacterial standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB23109
Antibacterial
Anti-infective peptides
Peptipedia
standard
No
A 35-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LRDLVCYCRTRGCKRRERMNGTCRKGHLLYTLCCR
Physicochemical Analysis
C173H298N64O46S7
AQIFPSW
R
4235.09
10.01
11
2
9
+8
7.26
-0.666
64.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
3355
79.22
12
Residue Composition
number
0
A
8
R
1
N
1
D
6
C
1
E
0
Q
3
G
1
H
0
I
5
L
2
K
1
M
0
F
0
P
0
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 8 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 5 K: 2 M: 1 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
35
C173H298N64O46S7
4235.09
10.01
+8
7.26
-0.666
Evidence Records 1 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against E. coli, S. typhimurium, and L. monocytogenes. ALso killed E. coli (99.9% killing at 41.9 ug/ml) and S. aureus (99.9% killing at 11.9 ug/ml) based on virtual colony count assays. This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h ( Wang et al., 2023 ).