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Peptide record

TPDB23024

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Anticancer Toxicity iDPPIV standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB23024
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Anticancer Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 iDPPIV pep-lab
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Anticancer, Toxicity, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, iDPPIV, and other sources, with an available 3D structural model.
Sequence
LPLPL
Physicochemical Analysis
C28H49N5O6
ARNDCEQGHIKMFSTWYV
L
551.73
6.02
0
0
3
-0
-0.78
1.640
234.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C28H49N5O6
551.73
6.02
-0
-0.78
1.640
551.7166
551.3671
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
>40 µg/mL
Cytotoxic
IC50 | >40 | µg/mL | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents | Mar Drugs | 2022
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2022 Feb 22 20(3):160.
Evidence 3 Activity

Activity

IC50
iDPPIV
325.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145, 845-852, 2014
2014
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C28H49N5O6/c1-16(2)13-19(29)26(36)32-11-7-9-22(32)24(34)30-20(14-17(3)4)27(37)33-12-8-10-23(33)25(35)31-21(28(38)39)15-18(5)6/h16-23H,7-15,29H2,1-6H3,(H,30,34)(H,31,35)(H,38,39)/t19-,20-,21-,22-,23-/m0/s1 InChIKey=KCPMPYBJPBRURZ-VUBDRERZSA-N
Additional Detail Fields 1 fields
5