Back to search

Peptide record

TPDB23015

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB23015
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides
Peptipedia CAFPdb dbAMP AHTPDB iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
LP
Physicochemical Analysis
C11H20N2O3
ARNDCEQGHIKMFSTWYV
LP
228.29
6.02
0
0
1
-0
-0.11
1.100
195.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H20N2O3
228.29
6.02
-0
-0.11
1.100
228.2873
228.1469
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
117.80 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wei D., Fan W., Xu Y.
Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis. Food Chem., 353, 129521, 2021
2021
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)O InChI=1S/C11H20N2O3/c1-7(2)6-8(12)10(14)13-5-3-4-9(13)11(15)16/h7-9H,3-6,12H2,1-2H3,(H,15,16)/t8-,9-/m0/s1 InChIKey: VTJUNIYRYIAIHF-IUCAKERBSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3180) Inhibitor of Xaa-Pro dipeptidase (EC 3.4.13.9) (MEROPS ID: M24.003) according to the BRENDA database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to the BRENDA database Peptide inducing the secretion of interferon-gamma by human CD+,4 T-lymphocytes according to the EROP-Moscow database. Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 528)
Evidence 2 Activity

Activity

IC50
Antihypertensive
117.80 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wei D., Fan W., Xu Y.
Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis. Food Chem., 353, 129521, 2021
2021
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)O InChI=1S/C11H20N2O3/c1-7(2)6-8(12)10(14)13-5-3-4-9(13)11(15)16/h7-9H,3-6,12H2,1-2H3,(H,15,16)/t8-,9-/m0/s1 InChIKey: VTJUNIYRYIAIHF-IUCAKERBSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3180) Inhibitor of Xaa-Pro dipeptidase (EC 3.4.13.9) (MEROPS ID: M24.003) according to the BRENDA database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to the BRENDA database Peptide inducing the secretion of interferon-gamma by human CD+,4 T-lymphocytes according to the EROP-Moscow database. Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 528)
Evidence 3 Activity

Activity

IC50
iDPPIV
2370.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chem., 134, 797-802, 2012
2012
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)O InChI=1S/C11H20N2O3/c1-7(2)6-8(12)10(14)13-5-3-4-9(13)11(15)16/h7-9H,3-6,12H2,1-2H3,(H,15,16)/t8-,9-/m0/s1 InChIKey: VTJUNIYRYIAIHF-IUCAKERBSA-N First reference concerning peptide: Bella A. M., Erickson R. H. Jr., Kim Y. S., Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme.Arch.Biochem.Biophys. 218 (1), 156-162(1982) Alternative IC50 value: 712.5 micromoles according to: Nongonierma A. B., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917 Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 10092) Inhibitor of Xaa-Pro dipeptidase (EC 3.4.13.9) (MEROPS ID: M24.003) according to the BRENDA database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to the BRENDA database Peptide inducing the secretion of interferon-gamma by human CD+,4 T-lymphocytes according to the EROP-Moscow database Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 528)
Additional Detail Fields 1 fields
2