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Peptide record

TPDB23004

Antibacterial Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB23004
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, AFP-GFuse, and ToxinPred 3.0, with an available 3D structural model.
Sequence
LNPLIKAGIFILKHRRPIGRGIEITGRGIKKFFSK
Physicochemical Analysis
C186H313N55O41
DCQMWYV
I
3975.88
12.43
10
1
14
+8
5.40
-0.037
114.29
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
4
R
1
N
0
D
0
C
1
E
0
Q
5
G
1
H
7
I
3
L
5
K
0
M
3
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 7 L: 3 K: 5 M: 0 F: 3 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
35
C186H313N55O41
3975.88
12.43
+8
5.40
-0.037
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

from ref AP3431: active against Gram- bacteria E. coli ATCC 25922 (MIC 0.5 uM), P-aeruginosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
5.3 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

NA

Other

t Gram- bacteria E. coli ATCC 25922 (MIC 0.5 uM), P-aeruginosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0
Evidence 3 Activity

Activity

MIC
Antibacterial
1.0 µM

Target

A. baumannii KCTC 23254

Source & Reference

NA

Other

inosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 1
Evidence 4 Activity

Activity

MIC
Antibacterial
3.0 µM

Target

p. pneumoniae KCTC 1726

Source & Reference

NA

Other

himurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (M
Evidence 5 Activity

Activity

MIC
Antibacterial
8.8 µM

Target

p. cloacae ATCC 13047

Source & Reference

NA

Other

3254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. f
Evidence 6 Activity

Activity

MIC
Antibacterial
0.3 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae AT
Evidence 7 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

B. cereus ATCC 10876

Source & Reference

NA

Other

subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalact
Evidence 8 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi
Evidence 9 Activity

Activity

MIC
Antibacterial
2.0 µM

Target

Streptococcus agalactiae ATCC 27956

Source & Reference

NA

Other

538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.
Evidence 10 Activity

Activity

MIC
Antibacterial
3.5 µM

Target

S. dysgalactiae ATCC 27957

Source & Reference

NA

Other

(MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KC
Evidence 11 Activity

Activity

MIC
Antibacterial
2.3 µM

Target

p. zooepidemicus ATCC 43079

Source & Reference

NA

Other

agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC
Evidence 12 Activity

Activity

MIC
Antibacterial
10.1 µM

Target

Candida albicans KCTC 7270

Source & Reference

NA

Other

7 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC 1.3 uM).
Evidence 13 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

C. cuniculi KCTC 17232

Source & Reference

NA

Other

icus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC 1.3 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
0.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

from ref AP3431: active against Gram- bacteria E. coli ATCC 25922 (MIC 0.5 uM), P-aeruginosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC
Evidence 15 Activity

Activity

MIC
Antifungal
5.3 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

NA

Other

t Gram- bacteria E. coli ATCC 25922 (MIC 0.5 uM), P-aeruginosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0
Evidence 16 Activity

Activity

MIC
Antifungal
1.0 µM

Target

A. baumannii KCTC 23254

Source & Reference

NA

Other

inosa ATCC 27853 (MIC >10.1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 1
Evidence 17 Activity

Activity

MIC
Antifungal
3.0 µM

Target

p. pneumoniae KCTC 1726

Source & Reference

NA

Other

himurium ATCC 14028 (MIC 5.3 uM), A. baumannii KCTC 23254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (M
Evidence 18 Activity

Activity

MIC
Antifungal
8.8 µM

Target

p. cloacae ATCC 13047

Source & Reference

NA

Other

3254 (MIC 1.0 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. f
Evidence 19 Activity

Activity

MIC
Antifungal
0.3 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

KCTC 1726 (MIC 3.0 uM), E. cloacae subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae AT
Evidence 20 Activity

Activity

MIC
Antifungal
0.8 µM

Target

B. cereus ATCC 10876

Source & Reference

NA

Other

subsp. cloacae ATCC 13047 (MIC 8.8 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalact
Evidence 21 Activity

Activity

MIC
Antifungal
1.3 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi
Evidence 22 Activity

Activity

MIC
Antifungal
2.0 µM

Target

Streptococcus agalactiae ATCC 27956

Source & Reference

NA

Other

538 (MIC 0.3 uM), B. cereus ATCC 10876 (MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.
Evidence 23 Activity

Activity

MIC
Antifungal
3.5 µM

Target

S. dysgalactiae ATCC 27957

Source & Reference

NA

Other

(MIC 0.8 uM), E. faecalis ATCC 29212 (MIC 1.3 uM), S. agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KC
Evidence 24 Activity

Activity

MIC
Antifungal
2.3 µM

Target

p. zooepidemicus ATCC 43079

Source & Reference

NA

Other

agalactiae ATCC 27956 (MIC 2.0 uM), S. dysgalactiae ATCC 27957 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC
Evidence 25 Activity

Activity

MIC
Antifungal
10.1 µM

Target

Candida albicans KCTC 7270

Source & Reference

NA

Other

7 (MIC 3.5 uM), S. equi subsp. zooepidemicus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC 1.3 uM).
Evidence 26 Activity

Activity

MIC
Antifungal
1.3 µM

Target

C. cuniculi KCTC 17232

Source & Reference

NA

Other

icus ATCC 43079 (MIC 2.3 uM). Also active against C. albicans KCTC 7270 (MIC 10.1 uM) and C. cuniculi KCTC 17232 (MIC 1.3 uM).
Evidence 27 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Genomewide Analysis and Biological Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity from Three Bat Species | Antibiotics (Basel) | 2022
Evidence 28 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Pig kidney epithelial cells PK15

Target

Pig kidney epithelial cells PK15

Source & Reference

NA
DBAASP
Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens | Vet Res | 2024
Evidence 29 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens | Vet Res | 2024
Evidence 30 Activity

Activity

7.7±0.2% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
7.7±0.2% Hemolysis | 80 | µg/mL | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens | Vet Res | 2024
Evidence 31 Activity

Activity

11.8±4.5% Hemolysis
Toxicity
160 µg/mL
Hemolytic Cytotoxic
11.8±4.5% Hemolysis | 160 | µg/mL | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens | Vet Res | 2024