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Peptide record

TPDB22905

Antibacterial Antiviral Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB22905
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
LLGDLLRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C199H344N60O53
ACHMWY
LK
4425.29
11.10
11
5
13
+6
13.97
-0.670
110.54
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
5
R
1
N
2
D
0
C
3
E
1
Q
2
G
0
H
3
I
6
L
6
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 2 C: 0 E: 3 Q: 1 G: 2 H: 0 I: 3 L: 6 K: 6 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C199H344N60O53
4425.29
11.10
+6
13.97
-0.670
Evidence Records 2 records
Evidence 1 Activity

Activity

50% cell death
Toxicity
18.4 µM
Cytotoxic
50% cell death | 18.4 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50=18.4 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.