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Peptide record

TPDB22904

Antibacterial Antiviral Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB22904
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
LLGDLLRKSKEKIGKEFKRIVQR
Physicochemical Analysis
C124H220N38O32
ANCHMPTWY
K
2755.35
11.06
8
3
8
+5
9.46
-0.757
114.35
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
2
E
1
Q
2
G
0
H
2
I
4
L
5
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 2 L: 4 K: 5 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C124H220N38O32
2755.35
11.06
+5
9.46
-0.757
Evidence Records 2 records
Evidence 1 Activity

Activity

50% cell death
Toxicity
>35.4 µM
Cytotoxic
50% cell death | >35.4 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins | Antimicrob Agents Chemother | 2008
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.18591279]CEM-SS cells:TC50>35.4 µM.(TC50:the concentration that reduced cell viability by 50%)

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2008 Sep 52(9):3438-40.