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Peptide record

TPDB22901

LL-37 Antibacterial Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB22901
LL-37
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 38-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, CellPPD, CellPPD-MOD, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESC-NH2
Physicochemical Analysis
C208H345N61O54S1
AHMWY
K
4596.46
10.79
11
5
13
+6
12.59
-0.639
87.11
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
0
A
5
R
1
N
2
D
1
C
3
E
1
Q
2
G
0
H
3
I
4
L
6
K
0
M
4
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 2 C: 1 E: 3 Q: 1 G: 2 H: 0 I: 3 L: 4 K: 6 M: 0 F: 4 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C208H345N61O54S1
4596.46
10.79
+6
12.59
-0.639
Amidation
L
Antimicrobial
Linear
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

COS-7, HFL-1 and CHO-K1 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Antimicrobial
Protein derived
Nucleic acid
Nucleus
Membrane raft endocytosis and proteoglycan-dependent endocytic process
In vitro
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCC
Additional Detail Fields 1 fields
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCC