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Peptide record

TPDB22898

(S,R)-bis(LeuLeu) or 1a (S,S)-bis(LeuLeu) or 1a Dileucine dileucine (LL) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-leucyl-L-leucine (Leu-Leu) ACE inhibitors Antibacterial Antifungal Antihypertensive Antiviral Bitter iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB22898
(S,R)-bis(LeuLeu) or 1a (S,S)-bis(LeuLeu) or 1a Dileucine dileucine (LL) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-leucyl-L-leucine (Leu-Leu)
ACE inhibitors Antibacterial Antifungal Antihypertensive Antiviral Bitter iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb AHTPDB dbAMP 3.0 Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LL
Physicochemical Analysis
C12H24N2O3
ARNDCEQGHIKMFPSTWYV
L
244.33
6.02
0
0
2
-0
-1.12
3.800
390.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C12H24N2O3
244.33
6.02
-0
-1.12
3.800
244.3296
244.1781
Self-Assembly Information 6 records
Record 1 Selfassembly

Source

21085503
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Straight fibers
temperature: Room temperature solvent: Water/DMSO
Selfassembly; Nanostructure=Nanofiber; Straight fibers; Trigger=temperature: Room temperature; solvent: Water/DMSO
Transmission Electron Microscopy (TEM)
Selfassembly
Record 2 Selfassembly

Source

21085503
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Fibers
temperature: Room temperature solvent: Water/DMSO
Selfassembly; Nanostructure=Nanofiber; Fibers; Trigger=temperature: Room temperature; solvent: Water/DMSO
Transmission Electron Microscopy (TEM)
Selfassembly
Record 3 Selfassembly

Source

24895323
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanotube Nanotubes
temperature: Room temperature solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
Selfassembly; Nanostructure=Nanotube; Nanotubes; Trigger=temperature: Room temperature; solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol); concentration: 2mg/ml
ESEM (Environmental Scanning Electron Microscope)
Selfassembly
Record 4 Selfassembly

Source

24895323
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber, Nanowire Needle like wire -Nanofibril structure
temperature: 180 °C solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
Selfassembly; Nanostructure=Nanofiber, Nanowire; Needle like wire -Nanofibril structure; Trigger=temperature: 180 °C; solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol); concentration: 2mg/ml
ESEM (Environmental Scanning Electron Microscope)
Selfassembly
Record 5 Selfassembly

Source

28508902
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Nanofibres
temperature: Room temperature solvent: methanol/n-butanol and methanol/acetonitrile concentration: 1:01
Selfassembly; Nanostructure=Nanofiber; Nanofibres; Trigger=temperature: Room temperature; solvent: methanol/n-butanol and methanol/acetonitrile; concentration: 1:01
atomic force microscopy and X-ray powder diffraction
Selfassembly
Record 6 Selfassembly

Source

27841381
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
Selfassembly; Nanostructure=Nanoparticles
TEM and SEM
Selfassembly
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Bella A. M., Erickson R. H. Jr., Kim Y. S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme. Arch. Biochem. Biophys., 218 (1), 156-162 (1982)
1982
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CC(C)C InChI=1S/C12H24N2O3/c1-7(2)5-9(13)11(15)14-10(12(16)17)6-8(3)4/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)/t9-,10-/m0/s1 InChIKey: LCPYQJIKPJDLLB-UWVGGRQHSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Peptide found in whey protein hydrolysate: Morifuji M., Koga J., Kawanaka K., Higuchi M., 2009, Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake in L6 myotubes and isolated skeletal muscles. J. Nutr. Sci. Vitaminol., 55, 81-86 Peptide reveals also glucose uptake stimulating activity (BIOPEP ID 8326). Another reference concerning peptide: Tulipano G., Sibilia V., Caroli A. M., Cocchi D., 2011, Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors. Peptides, 32, 835-838 Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M01.010) according to the BRENDA database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROP ID: S08.019) according to the BRENDA database Glucose uptake stimulating peptide according to the BIOPEP-UWM database of bioactive peptides Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 160) the ChEMBL database the PubChem database
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Straight fibers Trigger=temperature: Room temperature solvent: Water/DMSO
Nanofiber Straight fibers

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Water/DMSO
Transmission Electron Microscopy (TEM)
21085503
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Fibers Trigger=temperature: Room temperature solvent: Water/DMSO
Nanofiber Fibers

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Water/DMSO
Transmission Electron Microscopy (TEM)
21085503
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanotube Nanotubes Trigger=temperature: Room temperature solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
Nanotube Nanotubes

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
ESEM (Environmental Scanning Electron Microscope)
24895323
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber, Nanowire Needle like wire -Nanofibril structure Trigger=temperature: 180 °C solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
Nanofiber, Nanowire Needle like wire -Nanofibril structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 180 °C solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml
ESEM (Environmental Scanning Electron Microscope)
24895323
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Nanofibres Trigger=temperature: Room temperature solvent: methanol/n-butanol and methanol/acetonitrile concentration: 1:01
Nanofiber Nanofibres

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: methanol/n-butanol and methanol/acetonitrile concentration: 1:01
atomic force microscopy and X-ray powder diffraction
28508902
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 7 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
TEM and SEM
27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1888 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: Room temperature solvent: Water/DMSO solvent: HFP (1,1,1,3,3,3-hexafluoro-2-propanol) concentration: 2mg/ml temperature: 180 °C solvent: methanol/n-butanol and methanol/acetonitrile concentration: 1:01
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1888 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
21085503 24895323 28508902 27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly