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Peptide record

TPDB22895

Antibacterial Antifungal Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB22895
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
LKXLKXG
Physicochemical Analysis
C26H51N7O6
ARNDCEQHIMFPSTWYV
LK
557.73
10.60
2
0
2
+2
0.87
-0.086
111.43
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C26H51N7O6
557.73
10.60
+2
0.87
-0.086
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
50% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015
Evidence 2 Activity

Activity

13% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
13% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide. | Eur J Med Chem | 2015