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Peptide record

TPDB22893

Antibacterial Antifungal Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB22893
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
LKWXKKXLKWXKKX
Physicochemical Analysis
C70H116N18O11
ARNDCEQGHIMFPSTYV
K
1385.81
11.21
6
0
4
+6
1.12
-1.257
55.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
793.76
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C70H116N18O11
1385.81
11.21
+6
1.12
-1.257
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human normal embryonic lung cells L132

Target

Human normal embryonic lung cells L132

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021