Back to search

Peptide record

TPDB22888

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB22888
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
LKWLKKLLKWLKKL
Physicochemical Analysis
C94H160N22O15
ARNDCEQGHIMFPSTYV
LK
1838.44
11.21
6
0
8
+6
-1.12
-0.171
167.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
598.33
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C94H160N22O15
1838.44
11.21
+6
-1.12
-0.171
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli DH5alpha

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumonia
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. typhi TY2S

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. gru
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

a (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstand
Evidence 6 Activity

Activity

MIC
Antibacterial
5 µM

Target

Candida albicans

Source & Reference

NA

Other

a (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC
Evidence 7 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

C. neoformans

Source & Reference

NA

Other

TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC values resulted from 4 h in
Evidence 8 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

C. grubii

Source & Reference

NA

Other

10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC values resulted from 4 h incubation of bacteria in 10 m
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli DH5alpha

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumonia
Evidence 10 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (
Evidence 11 Activity

Activity

MIC
Antifungal
5 µM

Target

S. typhi TY2S

Source & Reference

NA

Other

active against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (
Evidence 12 Activity

Activity

MIC
Antifungal
10 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

against E. coli DH5alpha (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. gru
Evidence 13 Activity

Activity

MIC
Antifungal
5 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

a (MIC 5 uM), P. aeruginosa (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstand
Evidence 14 Activity

Activity

MIC
Antifungal
5 µM

Target

Candida albicans

Source & Reference

NA

Other

a (MIC 10 uM), S. typhi TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC
Evidence 15 Activity

Activity

MIC
Antifungal
2.5 µM

Target

C. neoformans

Source & Reference

NA

Other

TY2S (MIC 5 uM), S. aureus (MIC 10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC values resulted from 4 h in
Evidence 16 Activity

Activity

MIC
Antifungal
2.5 µM

Target

C. grubii

Source & Reference

NA

Other

10 uM), K. pneumoniae (MIC 5 uM), C. albicans (MIC 5 uM), C. neoformans (MIC 2.5 uM), and C. grubii (MIC 2.5 uM). Nonstandard assays: Very low MIC values resulted from 4 h incubation of bacteria in 10 m
Evidence 17 Activity

Activity

90% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
90% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021
Evidence 18 Activity

Activity

LC50
Toxicity
10-20 µM
Cytotoxic
LC50 | 10-20 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021
Evidence 19 Activity

Activity

LC50
Toxicity
10-20 µM
Cytotoxic
LC50 | 10-20 | µM | target cell: Human normal embryonic lung cells L132

Target

Human normal embryonic lung cells L132

Source & Reference

NA
DBAASP
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. | ChemMedChem | 2021