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Peptide record

TPDB22866

FM-Cathelicidin Antibacterial Anticancer Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB22866
FM-Cathelicidin
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia DBAASP
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and DBAASP, with an available 3D structural model.
Sequence
LKTKALNKLKQKLQAVGNLIGSVIKG
Physicochemical Analysis
C125H228N36O33
RDCEHMFPWY
K
2763.41
11.21
6
0
11
+6
4.62
-0.004
135.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
2
A
0
R
2
N
0
D
0
C
0
E
2
Q
3
G
0
H
2
I
5
L
6
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 5 K: 6 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
26
C125H228N36O33
2763.41
11.21
+6
4.62
-0.004
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Cytotoxicity
Toxicity
<20 µM
Cytotoxic
0% Cytotoxicity | <20 | µM | target cell: Murine alveolar macrophages MH-S

Target

Murine alveolar macrophages MH-S

Source & Reference

NA
DBAASP
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. | Front Pharmacol | 2021
Evidence 2 Activity

Activity

<10% Cytotoxicity
Toxicity
40 µM
Cytotoxic
<10% Cytotoxicity | 40 | µM | target cell: Murine alveolar macrophages MH-S

Target

Murine alveolar macrophages MH-S

Source & Reference

NA
DBAASP
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. | Front Pharmacol | 2021
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
<20 µM
Cytotoxic
0% Cytotoxicity | <20 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. | Front Pharmacol | 2021
Evidence 4 Activity

Activity

<10% Cytotoxicity
Toxicity
40 µM
Cytotoxic
<10% Cytotoxicity | 40 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. | Front Pharmacol | 2021
Evidence 5 Activity

Activity

<1% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
<1% Hemolysis | 40 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis. | Front Pharmacol | 2021
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Pharmacol. 2021 Aug 16 12:731056.
Evidence 7 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP