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Peptide record

TPDB22829

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB22829
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, CancerPPD 2.0, and dbACP, with an available 3D structural model.
Sequence
LKKLFKKILKYL
Physicochemical Analysis
C78H135N17O14
ARNDCEQGHMPSTWV
K
1535.04
10.77
5
0
7
+5
0.33
0.142
162.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
97.07
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C78H135N17O14
1535.04
10.77
+5
0.33
0.142
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
73.7±4.5 µM
Cytotoxic
IC50 | 73.7±4.5 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
10% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
15% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel peptides based on antimicrobial peptides as potential agents with anti-tumor and multidrug resistance-reversing activities | Chem Biol Drug Des | 2017
Evidence 4 Activity

Activity

IC50
Toxicity
73.7
Hemolytic Cytotoxic
Hemolytic_activity: Rabbit red blood cells: very low hemolytic activity even at the concentration of 160 µm(as show in fig.3) | Cytotoxicity: GES-1: IC50=73.7±4.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Nov 90(5):972-980.