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Peptide record

TPDB22784

K17I] Latarcin-3a (5-17) [M5,13L Lt-MAP2 A6I E14K Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB22784
K17I] Latarcin-3a (5-17) [M5,13L Lt-MAP2 A6I E14K
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP DBAASP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
LIKKLKEYLKKLI
Physicochemical Analysis
C80H144N18O17
ARNDCQGHMFPSTWV
K
1630.13
10.47
5
1
7
+4
3.17
-0.008
180.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
91.40
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
2
I
4
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C80H144N18O17
1630.13
10.47
+4
3.17
-0.008
Free
L
Linear
Free
Antimicrobial and Antitumor
Synthetic Derivative of Lataracin-3a
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

A. baumannii ATCC 003321216

Source & Reference

NA

Other

Active against Gram- A. baumannii ATCC 003321216 (MIC 8 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K. pneumoniae ATCC 13883 (MIC 32-64 ug/ml), P.aerugi
Evidence 2 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

E.coli ATCC 25922

Source & Reference

NA

Other

Active against Gram- A. baumannii ATCC 003321216 (MIC 8 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K. pneumoniae ATCC 13883 (MIC 32-64 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml)
Evidence 3 Activity

Activity

MIC
Antibacterial
32-64 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

NA

Other

inst Gram- A. baumannii ATCC 003321216 (MIC 8 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K. pneumoniae ATCC 13883 (MIC 32-64 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P. acnes ATCC 51277 (MIC 64 ug/ml) a
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

P. acnes ATCC 51277

Source & Reference

NA

Other

umoniae ATCC 13883 (MIC 32-64 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P. acnes ATCC 51277 (MIC 64 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A
Evidence 5 Activity

Activity

EC50
EC50 = 43.9 ± 0.5 µg/mL
Anticancer
43.9

Target

Blood Cancer
C1498
Blood

Assay & Model

Cytotoxicity assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 6 Activity

Activity

EC50
EC50 = 44 ± 3 µg/mL
Anticancer
44

Target

Blood Cancer
K-562
Blood

Assay & Model

Cytotoxicity assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2022
Evidence 7 Activity

Activity

<10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin. | Front Microbiol | 2022
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2022 Sep 21 13:965622.
Evidence 9 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP