Back to search

Peptide record

TPDB22701

Antibacterial Anticancer Antiviral Toxicity modified_plain modified
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB22701
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 DRAVP 2.0
modified_plain
Yes
A 28-aa modified multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, and DRAVP 2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
LEANIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
C141H241N37O50
RDCGHMFPSTWYV
E
3254.68
4.55
6
9
8
-3
22.67
-1.493
90.71
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
0
R
2
N
0
D
0
C
9
E
2
Q
0
G
0
H
1
I
5
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 0 E: 9 Q: 2 G: 0 H: 0 I: 1 L: 5 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C141H241N37O50
3254.68
4.55
-3
22.67
-1.493
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
130.07±15.27 µM
Cytotoxic
50% Cytotoxicity | 130.07±15.27 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
46.83±4.65 µM
Cytotoxic
50% Cytotoxicity | 46.83±4.65 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30089693]TZM-bl cell:CC50=434.03±90.38 µM ##MT-4 cell:CC50=135.07±32.3 µM ##HEK293T cell:CC50=130.07± 15.27µM ##PBMC:CC50=46.83±4.65 µM.

Source & Reference

NA
DRAMP
J Virol. 2018 Sep 26 92(20):e01088-18.