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Peptide record

TPDB22664

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB22664
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KXRRYXYRQRXVTYXRGR
Physicochemical Analysis
C85H140N34O20
ANDCEHILMFPSW
R
1958.26
12.12
7
0
4
+7
3.83
-1.956
16.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4470
228.26
5
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 1
Chemical Descriptors
18
C85H140N34O20
1958.26
12.12
+7
3.83
-1.956
Evidence Records 4 records
Evidence 1 Activity

Activity

20.9±3.1% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
20.9±3.1% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
30.8±2.0 µM
Cytotoxic
CC50 | 30.8±2.0 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

CC50
Toxicity
9.5±0.5 µM
Cytotoxic
CC50 | 9.5±0.5 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
3.1 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 20.9±3.1% Hemolysis=64µM | Cytotoxicity: HFF-1: CC50=30.8±2.0µM PBMC: CC50=9.5±0.5µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334.