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Peptide record

TPDB22642

Antibacterial Toxicity modified_plain modified
15 amino acids
Basic Information
3D PDB MODEL
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TPDB22642
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 15-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KXAKWXKKXAKAXAK
Physicochemical Analysis
C59H104N18O12
RNDCEQGHILMFPSTYV
K
1257.59
11.21
6
0
5
+6
3.41
-1.140
26.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
437.35
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
15
C59H104N18O12
1257.59
11.21
+6
3.41
-1.140
Evidence Records 6 records
Evidence 1 Activity

Activity

38.5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
38.5% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
22% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 3 Activity

Activity

32.6% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
32.6% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 4 Activity

Activity

19.5% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
19.5% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 5 Activity

Activity

25.5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
25.5% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015
Evidence 6 Activity

Activity

13.5% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
13.5% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. | Bioorg Med Chem Lett | 2015