TPDB

3D PDB MODEL

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TPDB ID TPDB22636

Activity

Antibacterial Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb dbAMP AI4AVP dbAMP 3.0 DRAVP 2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.

Sequence

LCLRNWDQGHRP

FASTA

>TPDB22636|Antibacterial;Antifungal;Antiviral;Toxicity|length=12
LCLRNWDQGHRP

Formula C64H99N23O17S1

Absent Amino Acids AEIKMFSTYV

Common Amino Acids RL

Mass 1494.69

PI 9.01

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 2.06

Hydrophobicity -1.292

Aliphatic Index 65.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 367.97

Polar Residues 3

number

0

A

2

R

1

N

1

D

1

C

0

E

1

Q

1

G

1

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 1 C: 1 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

12

Formula

C64H99N23O17S1

Mass

1494.69

PI

9.01

Net Charge

+1

Boman Index

2.06

Hydrophobicity

-1.292

Evidence 1 Activity

Activity

Activity Endpoint <10% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

<10% Killing | 100 | µg/mL | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins. | Intervirology | 2018

Evidence 2 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 500 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 500 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Target Cell Monkey kidney epithelial cells LLC-MK2

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Fungicidal activity of peptides encoded by immunoglobulin genes. | Sci Rep | 2017

Evidence 3 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Fungicidal activity of peptides encoded by immunoglobulin genes. | Sci Rep | 2017

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

Cytotoxicity: [Ref.30654366]<10% cytotoxicity against Vero cells at the concentration of 100µg/ mL.

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Intervirology. 2018 61(4):166-173.