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Peptide record

TPDB22621

14K K17L] Latarcin-3a (5-17) [M5,13L E11 K10A L16A Antibacterial Anticancer Toxicity standard

13 amino acids

3D PDB MODEL

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TPDB ID TPDB22621

Peptide_Name

14K K17L] Latarcin-3a (5-17) [M5,13L E11 K10A L16A

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia DBAASP

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and DBAASP, with an available 3D structural model.

Sequence

LAKKLAKYLKKAL

FASTA

>TPDB22621|Antibacterial;Anticancer;Toxicity|length=13
LAKKLAKYLKKAL

Formula C72H130N18O15

Absent Amino Acids RNDCEQGHIMFPSTWV

Common Amino Acids K

Mass 1487.94

PI 10.77

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +5

Boman Index 1.26

Hydrophobicity -0.015

Aliphatic Index 143.08

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 100.14

Polar Residues 1

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C72H130N18O15

Mass

1487.94

10.77

Net Charge

Boman Index

1.26

Hydrophobicity

-0.015

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against Active against Gram- A.baumannii ATCC 003321216 (MIC >128 ug/ml ~80 uM), E. coli ATCC 25922 (MIC 64 ug/ml), K. pneumoniae ATCC 13883 (MIC 32 ug/ml), K.pneumoniae KPC+ 001450421 (MIC>128 ug/ml), P.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source NA

Other

Evidence Text

- A.baumannii ATCC 003321216 (MIC >128 ug/ml ~80 uM), E. coli ATCC 25922 (MIC 64 ug/ml), K. pneumoniae ATCC 13883 (MIC 32 ug/ml), K.pneumoniae KPC+ 001450421 (MIC>128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism P. acnes ATCC 51277

Source & Reference

Database Source NA

Other

Evidence Text

oniae KPC+ 001450421 (MIC>128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P. acnes ATCC 51277 (MIC 16 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

also inhibits biofilm formation against A. baumannii ATCC 003321216 (MBIC 128 ug/ml) and E. coli ATCC 25922 (MIC 64 ug/ml). Deposited and provided by Felipe Nunes 12/2022.

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

NA | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin. | Front Microbiol | 2022

Evidence 6 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Front Microbiol. 2022 Sep 21 13:965623.

Evidence 7 Activity

Target

Target Organism Cutibacterium acnes

Source & Reference

Database Source DBAASP