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Peptide record

TPDB22580

Antibacterial Toxicity modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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TPDB22580
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 12-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KWXKKWXKWXKK
Physicochemical Analysis
C69H104N18O10
ARNDCEQGHILMFPSTYV
K
1345.70
11.21
6
0
3
+6
0.39
-2.175
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1226.13
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12
C69H104N18O10
1345.70
11.21
+6
0.39
-2.175
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of cell selective ?/?-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus. | Bioorg Chem | 2017
Evidence 2 Activity

Activity

13.4±11.5% Killing
Toxicity
250 µg/mL
Cytotoxic
13.4±11.5% Killing | 250 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design and synthesis of cell selective ?/?-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus. | Bioorg Chem | 2017