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Peptide record

TPDB22567

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB22567
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KYLNFAKWLKGANLAKYANA
Physicochemical Analysis
C109H166N28O26
RDCEQHIMPSTV
A
2284.69
10.41
4
0
12
+4
-2.16
-0.340
83.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8480
371.17
5
Residue Composition
number
5
A
0
R
3
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 0
Chemical Descriptors
20
C109H166N28O26
2284.69
10.41
+4
-2.16
-0.340
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>500 µM
Cytotoxic
50% Cell death | >500 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy. | Mol Cell Biochem | 2015
Evidence 2 Activity

Activity

IC50
Toxicity
500 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: NIH 3T3: IC50>500 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Biochem. 2015 Feb 400(1-2):77-86.