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Peptide record

TPDB22560

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB22560
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KWCIRVCRNGVCYRRCR
Physicochemical Analysis
C90H151N35O20S4
ADEQHLMFPST
R
2171.65
10.41
6
0
5
+6
1.55
-0.565
57.06
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7240
333.39
6
Residue Composition
number
0
A
5
R
1
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
17
C90H151N35O20S4
2171.65
10.41
+6
1.55
-0.565
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

M. luteus B-1314

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 8 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 o
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus 209P

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 8 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

B. subtilis B-886

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 8 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5 uM), E. cloacae CI 4172 (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Escherichia coli ML-35p or ATTC 25922 or CI 3600 or CI 214

Source & Reference

NA

Other

m+ M. luteus B-1314 (MIC 8 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5 uM), E. cloacae CI 4172 (MIC 4 uM), A. baumanii CI 2675 (MIC 0.5 uM), P. aeruginosa PAO1 (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Enterobacter cloacae CI 4172

Source & Reference

NA

Other

btilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5 uM), E. cloacae CI 4172 (MIC 4 uM), A. baumanii CI 2675 (MIC 0.5 uM), P. aeruginosa PAO1 (MIC 4 uM), and K. pneumonia ATCC 7
Evidence 6 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

A. baumanii CI 2675

Source & Reference

NA

Other

li ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5 uM), E. cloacae CI 4172 (MIC 4 uM), A. baumanii CI 2675 (MIC 0.5 uM), P. aeruginosa PAO1 (MIC 4 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

or CI 214 (MIC 0.5 uM), E. cloacae CI 4172 (MIC 4 uM), A. baumanii CI 2675 (MIC 0.5 uM), P. aeruginosa PAO1 (MIC 4 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µM

Target

K. pneumonia ATCC 700603

Source & Reference

NA

Other

CI 4172 (MIC 4 uM), A. baumanii CI 2675 (MIC 0.5 uM), P. aeruginosa PAO1 (MIC 4 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of Action and Therapeutic Potential of the β-Hairpin Antimicrobial Peptide Capitellacin from the Marine Polychaeta Capitella teleta | Mar Drugs | 2022