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Peptide record

TPDB22556

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB22556
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
KWCFRVCYRGICYRRCSG
Physicochemical Analysis
C98H150N32O22S4
ANDEQHLMPT
RC
2256.71
9.66
5
0
6
+5
-1.68
-0.306
37.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
386.85
7
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
1
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C98H150N32O22S4
2256.71
9.66
+5
-1.68
-0.306
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
10.3±0.4 µM
Cytotoxic
50% Cell death | 10.3±0.4 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties. | ACS Chem Biol | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>64 µM
Hemolytic Cytotoxic
50% Cell death | >64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties. | ACS Chem Biol | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human RBCs: CC50=10.3±0.4 µM | Cytotoxicity: HaCaT: CC50>64 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Dec 20 14(12):2895-2908.