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Peptide record

TPDB22552

Antibacterial Anticancer Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB22552
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and PD_Hemolysis, with an available 3D structural model.
Sequence
KWCFRVCYRGFCYRRCRK
Physicochemical Analysis
C108H164N36O21S4
ANDEQHILMPST
R
2430.96
10.36
7
0
6
+7
-0.84
-0.800
16.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
359.12
6
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
2
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
18
C108H164N36O21S4
2430.96
10.36
+7
-0.84
-0.800
Evidence Records 5 records
Evidence 1 Activity

Activity

Hemolysis
Human RBCs: CC50=8.4±1.2 µM

Target

Human RBCs

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
ACS Chem Biol. 2019 Dec 20 14(12):2895-2908.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Cell death
Toxicity
4.1±0.1 µM
Cytotoxic
50% Cell death | 4.1±0.1 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties. | ACS Chem Biol | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
8.4±1.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 8.4±1.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties. | ACS Chem Biol | 2019
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human RBCs: CC50=8.4±1.2 µM | Cytotoxicity: HaCaT: CC50=4.1±0.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Dec 20 14(12):2895-2908.
Evidence 5 Hemolysis

Activity

Human RBCs: CC50=8.4±1.2 µM
Hemolysis

Target

Human RBCs

Source & Reference

PD_Hemolysis
ACS Chem Biol. 2019 Dec 20 14(12):2895-2908.
DRAMP4
PD_Hemolysis