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Peptide record

TPDB22547

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Antifungal Antihypertensive Neuropeptide Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB22547
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Antifungal Antihypertensive Neuropeptide Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides Neuroactive peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KW
Physicochemical Analysis
C17H24N4O3
ARNDCEQGHILMFPSTYV
KW
332.40
10.10
1
0
1
+1
-0.86
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
1654.62
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C17H24N4O3
332.40
10.10
+1
-0.86
-2.400
332.3965
332.1843
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.63 µM
ACE inhibitor
ah

Source & Reference

NA
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C17H24N4O3/c18-8-4-3-6-13(19)16(22)21-15(17(23)24)9-11-10-20-14-7-2-1-5-12(11)14/h1-2,5,7,10,13,15,20H,3-4,6,8-9,18-19H2,(H,21,22)(H,23,24)/t13-,15-/m0/s1 InChIKey=RVKIPWVMZANZLI-ZFWWWQNUSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des., 13, 8, 773-791.
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.63 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C17H24N4O3/c18-8-4-3-6-13(19)16(22)21-15(17(23)24)9-11-10-20-14-7-2-1-5-12(11)14/h1-2,5,7,10,13,15,20H,3-4,6,8-9,18-19H2,(H,21,22)(H,23,24)/t13-,15-/m0/s1 InChIKey=RVKIPWVMZANZLI-ZFWWWQNUSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des., 13, 8, 773-791.
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003
Evidence 4 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
Additional Detail Fields 1 fields
2