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Peptide record

TPDB22541

LDP-NLS Antibacterial Antifungal Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB22541
LDP-NLS
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia Antifungipept CAFPdb dbAMP CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KWRRKLKKLRPKKKRKV
Physicochemical Analysis
C105H194N38O18
ANDCEQGHIMFSTY
K
2276.94
12.90
12
0
4
+12
8.71
-2.347
62.94
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
241.55
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
8
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 8 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
17
C105H194N38O18
2276.94
12.90
+12
8.71
-2.347
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mrsa And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC-labelled at N-terminus
LDP-NLS exhibited a 50% higher uptake into MRSA cells when compared to LDP
In vitro
CHHHHTTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293 T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Chimeric
rNef-Vpr-Gp160-P24 protein
Able to deliver rNef-VprGp160-P24 peptide
In vitro
CCHHHHGGGCC
Additional Detail Fields 1 fields
CHHHHTTTCC CCHHHHGGGCC