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Peptide record

TPDB22538

Antibacterial Anticancer Antifungal Antiparasitic standard

19 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB22538

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.

Sequence

KWQNALLHHGLNCAKGVLK

FASTA

>TPDB22538|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=19
KWQNALLHHGLNCAKGVLK

Formula C96H156N30O23S1

Absent Amino Acids RDEIMFPSTY

Common Amino Acids L

Mass 2130.54

PI 10.32

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index 1.73

Hydrophobicity -0.253

Aliphatic Index 107.89

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 258.15

Polar Residues 4

number

Amino Acid Distribution

A: 2 R: 0 N: 2 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 2 I: 0 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

Formula

C96H156N30O23S1

Mass

2130.54

10.32

Net Charge

Boman Index

1.73

Hydrophobicity

-0.253

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resis

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism B. subtilis KCTC 2213

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 ant

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism M. luteus KCTC 9341

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source NA

Other

Evidence Text

subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism L. monocytogenes CCARM 2161

Source & Reference

Database Source NA

Other

Evidence Text

omycin-resistant E. faecium strain CCARM 5028 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoc

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa CCARM 2161 MDRPA

Source & Reference

Database Source NA

Other

Evidence Text

28 anti-VRE (MIC 4 ug/ml), multidrug-resistant L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 23

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli KCTC 1039

Source & Reference

Database Source NA

Other

Evidence Text

L. monocytogenes CCARM 2161 (MIC 4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCT

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Klebsiella oxytoca KCTC 1686

Source & Reference

Database Source NA

Other

Evidence Text

4 ug/ml), P. aeruginosa CCARM 2161 MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. a

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii KCTC 2359

Source & Reference

Database Source NA

Other

Evidence Text

MDRPA (MIC 4 ug/ml), E. coli KCTC 1039 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism S. enterica KCTC 2930

Source & Reference

Database Source NA

Other

Evidence Text

9 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source CAFPdb

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resis

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism B. subtilis KCTC 2213

Source & Reference

Database Source CAFPdb

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 ant

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism M. luteus KCTC 9341

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism L. monocytogenes CCARM 2161

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa CCARM 2161 MDRPA

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli KCTC 1039

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Klebsiella oxytoca KCTC 1686

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii KCTC 2359

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism S. enterica KCTC 2930

Source & Reference

Database Source CAFPdb

Other

Evidence Text

9 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source CAFPdb

Other

Evidence Text

/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resis

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µg/mL

Target

Target Organism B. subtilis KCTC 2213

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis KCTC 2213 (MIC 1 ug/ml), M. luteus KCTC 9341 (MIC 2 ug/ml), vancomycin-resistant E. faecium strain CCARM 5028 ant

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism M. luteus KCTC 9341

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism L. monocytogenes CCARM 2161

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa CCARM 2161 MDRPA

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli KCTC 1039

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Klebsiella oxytoca KCTC 1686

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii KCTC 2359

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism S. enterica KCTC 2930

Source & Reference

Database Source NA

Other

Evidence Text

9 (MIC 4 ug/ml), K. oxytoca KCTC 1686 (MIC 4 ug/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8-16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

/ml), C. freundii KCTC 2359 (MIC 4 ug/ml), S. enterica KCTC 2930 (MIC 4 ug/ml), 5 strains C. albicans (MIC 8-16 ug/ml). More to be added.