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Peptide record

TPDB22518

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB22518
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP HemoPI PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KWKW
Physicochemical Analysis
C34H46N8O5
ARNDCEQGHILMFPSTYV
KW
646.79
10.60
2
0
2
+2
-1.72
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
1700.71
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C34H46N8O5
646.79
10.60
+2
-1.72
-2.400
Evidence Records 8 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action. | Br J Pharmacol | 2019
Evidence 2 Activity

Activity

12% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

16% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
16% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

37% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
37% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
550 µM
Hemolytic Cytotoxic
10% Hemolysis | 550 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides. | Amino Acids | 2013
Evidence 7 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antifungal and Antibiofilm Activities and the Mechanism of Action of Repeating Lysine-Tryptophan Peptides against Candida albicans | Microorganisms | 2020
Evidence 8 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis