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Peptide record

TPDB22517

Antibacterial Antiparasitic Hemolysis Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB22517
Antibacterial Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Antiparasitic, Hemolysis, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, HemoPI, and other sources, with an available 3D structural model.
Sequence
KWKVFKKIEKNGRNIRNGIVKAGPAIAVLGEAKAL
Physicochemical Analysis
C175H298N52O43
DCQHMSTY
K
3818.61
11.23
9
2
16
+7
8.36
-0.226
106.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
144.03
3
Residue Composition
number
5
A
2
R
3
N
0
D
0
C
2
E
0
Q
4
G
0
H
4
I
2
L
7
K
0
M
1
F
1
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 3 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 7 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C175H298N52O43
3818.61
11.23
+7
8.36
-0.226
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>100 µg/mL
Cytotoxic
50% Cell death | >100 | µg/mL | target cell: Human dendritic cells

Target

Human dendritic cells

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis