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Peptide record

TPDB22469

Antibacterial Antiparasitic Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB22469
Antibacterial Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antiparasitic, Hemolysis, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, HemoPI, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIEKVGQNIRDGIIKAGPAVAWVGQATQIAK
Physicochemical Analysis
C190H313N53O47
CHMSY
K
4091.90
10.91
8
2
17
+6
6.20
-0.211
100.27
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
268.82
5
Residue Composition
number
5
A
1
R
1
N
1
D
0
C
1
E
3
Q
4
G
0
H
5
I
1
L
7
K
0
M
1
F
1
P
0
S
1
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 3 G: 4 H: 0 I: 5 L: 1 K: 7 M: 0 F: 1 P: 1 S: 0 T: 1 W: 2 Y: 0 V: 3
Chemical Descriptors
37
C190H313N53O47
4091.90
10.91
+6
6.20
-0.211
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>100 µg/mL
Cytotoxic
50% Cell death | >100 | µg/mL | target cell: Human dendritic cells

Target

Human dendritic cells

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis