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Peptide record

TPDB22465

Synthetic peptide Antibacterial Anticancer Antifungal standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB22465
Synthetic peptide
Antibacterial Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab CAFPdb
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
KWKKLLKKPPPLLKKLLKKL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C122H218N30O21
ARNDCEQGHIMFSTYV
K
2441.26
11.41
9
0
8
+9
0.66
-0.710
136.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
2.25
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
7
L
9
K
0
M
0
F
3
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 9 M: 0 F: 0 P: 3 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20 reviewed residue count
C122H218N30O21 sequence-only estimate (linear, free termini)
2441.26 sequence-only estimate (linear, free termini)
11.41 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
0.66 sequence-only estimate (linear, free termini)
-0.710 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
Antimicrobial and Anticancer, antibacterial, antifungal Activity
Synthetic peptide Activity
Evidence Records 3 records
Evidence 1 Activity

Activity

0% survival rate at 100 µM
Anticancer

Target

Blood Cancer
Jurkat
Blood

Assay & Model

MTT/MTS assay

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
US_6800727_B2

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

~20% survival rate at 10 µM
Anticancer

Target

Gastric Cancer
SNU-601
Stomach

Assay & Model

MTT/MTS assay

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
US_6800727_B2
Evidence 3 Activity

Activity

0% survival rate at 100 µM
Anticancer

Target

Gastric Cancer
SNU-601
Stomach

Assay & Model

MTT/MTS assay

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
US_6800727_B2