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Peptide record

TPDB22463

Antibacterial Anticancer Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB22463
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KWKKLLKKLLXLLKKLLK
Physicochemical Analysis
C107H196N26O18
ARNDCEQGHIMFPSTYV
LK
2134.90
11.36
8
0
9
+8
1.59
-0.094
173.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
257.62
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
8
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C107H196N26O18
2134.90
11.36
+8
1.59
-0.094
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues. | Biochemistry | 2005
Evidence 2 Activity

Activity

IC50
Toxicity
1.0 µM
Cytotoxic
IC50 | 1.0 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues. | Biochemistry | 2005
Evidence 3 Activity

Activity

IC50
Toxicity
1 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis=100 µM | Cytotoxicity: NIH 3T3: IC50=1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochemistry. 2005 Sep 13 44(36):12094-106.