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Peptide record

TPDB22457

Antibacterial Anticancer Antifungal Antiparasitic standard

19 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB22457

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KWKKALLHHGLNCAKGVLA

FASTA

>TPDB22457|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=19
KWKKALLHHGLNCAKGVLA

Formula C96H159N29O21S1

Absent Amino Acids RDEQIMFPSTY

Common Amino Acids LK

Mass 2087.56

PI 10.55

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +4

Boman Index 1.55

Hydrophobicity 0.005

Aliphatic Index 113.16

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 263.47

Polar Residues 2

number

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

Formula

C96H159N29O21S1

Mass

2087.56

10.55

Net Charge

Boman Index

1.55

Hydrophobicity

0.005

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VR

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocyt

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source NA

Other

Evidence Text

against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml)

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

C 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. f

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa MDRPA

Source & Reference

Database Source NA

Other

Evidence Text

ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

nti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source NA

Other

Evidence Text

L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii

Source & Reference

Database Source NA

Other

Evidence Text

/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VR

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocyt

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P.

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa MDRPA

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

nti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source NA

Other

Evidence Text

L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii

Source & Reference

Database Source NA

Other

Evidence Text

/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus MRSA

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VR

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocyt

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

active against S. aureus MRSA (MIC 4 ug/ml), B. subtilis (MIC 2 ug/ml), M. luteus (MIC 4 ug/ml), E. faecium strain CCARM 5028 anti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P.

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism E. faecium strain CCARM 5028 anti-VRE

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa MDRPA

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

nti-VRE (MIC 2 ug/ml), L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source NA

Other

Evidence Text

L. monocytogenes (MIC 2 ug/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism Citrobacter freundii

Source & Reference

Database Source NA

Other

Evidence Text

/ml), P. aeruginosa MDRPA (MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

MIC 4 ug/ml), E. coli (MIC 2 ug/ml), K. oxytoca (MIC 2 ug/ml), C. freundii (MIC 4 ug/ml), S. enterica (MIC 2 ug/ml).