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Peptide record

TPDB22447

Antibacterial Antifungal Antiparasitic Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB22447
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept dbAMP 3.0 i2APP
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, Antifungipept, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
KWKFFKKIERVGQNIRDGIIKAGPAVQVVGQAATIYKGK
Physicochemical Analysis
C201H329N57O50
CHLMS
K
4344.18
10.93
9
2
17
+7
7.60
-0.300
90.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
160.91
6
Residue Composition
number
4
A
2
R
1
N
1
D
0
C
1
E
3
Q
5
G
0
H
5
I
0
L
7
K
0
M
2
F
1
P
0
S
1
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 3 G: 5 H: 0 I: 5 L: 0 K: 7 M: 0 F: 2 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 4
Chemical Descriptors
39
C201H329N57O50
4344.18
10.93
+7
7.60
-0.300
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It exhibited significant (P
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It exhibited significant (P
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It exhibited significant (P
Evidence 4 Activity

Activity

<10% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
<10% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 5 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019