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Peptide record

TPDB22423

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB22423
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
KWXWKXVKXVK
Physicochemical Analysis
C56H88N14O9
ARNDCEQGHILMFPSTY
K
1101.40
11.00
4
0
4
+4
0.40
-0.818
52.73
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
998.73
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
11
C56H88N14O9
1101.40
11.00
+4
0.40
-0.818
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
0% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency. | Antimicrob Agents Chemother | 2011
Evidence 2 Activity

Activity

12% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
12% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency. | Antimicrob Agents Chemother | 2011