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Peptide record

TPDB22421

Antibacterial Anticancer Antifungal Antiparasitic Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB22421
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
KWXWKXAKXAK
Physicochemical Analysis
C52H80N14O9
RNDCEQGHILMFPSTYV
K
1045.30
11.00
4
0
4
+4
-0.08
-1.255
18.18
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
1052.33
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
11
C52H80N14O9
1045.30
11.00
+4
-0.08
-1.255
Evidence Records 4 records
Evidence 1 Activity

Activity

15% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
15% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro antibacterial and antimalarial activity of dehydrophenylalanine-containing undecapeptides alone and in combination with drugs. | Int J Antimicrob Agents | 2012
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro antibacterial and antimalarial activity of dehydrophenylalanine-containing undecapeptides alone and in combination with drugs. | Int J Antimicrob Agents | 2012
Evidence 3 Activity

Activity

3% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
3% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action of novel synthetic dodecapeptides against Candida albicans. | Biochim Biophys Acta | 2013
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Nov 1830(11):5193-203